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Carbon monoxide poisoning is the most common type of fatal air poisoning in many countries. Carbon monoxide is colorless, odorless, and tasteless, but highly toxic. It combines with hemoglobin to produce carboxyhemoglobin, which usurps the space in hemoglobin that normally carries oxygen, but is ineffective for delivering oxygen to bodily tissues.

Concentrations as low as 667ppm, may cause up to 50% of the body's hemoglobin to convert to carboxyhemoglobin. A level of 50% carboxyhemoglobin may result in seizure, coma, and fatality. In the United States, the OSHA limits long-term workplace exposure levels above 50 ppm.

The most common symptoms of carbon monoxide poisoning may resemble other types of poisonings and infections, including symptoms such as headachenauseavomitingdizzinessfatigue, and a feeling of weakness. Affected families often believe they are victims of food poisoning. Neurological signs include confusion, disorientation, visual disturbance, syncope and seizures.