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Small levels of nitrogen oxides can irritate the eyes and/or nose, cause nausea, may cause fluid to form in the lungs, and cause shortness of breath. Exposure to high levels of nitrogen oxides can lead to rapid, burning spasms, cause the throat to swell, reduce oxygen intake, cause a larger build-up of fluids in the lungs, and sometimes even death. Many scientific studies have found a relationship between high levels of nitrogen oxides and sulphur dioxide and increased sickness and premature death from cardiac and respiratory disorders.